Which 15 drugs get Medicare negotiated prices in 2027?

Medicare negotiated prices for 15 more Part D drugs take effect January 1, 2027. They include Ozempic, Rybelsus and Wegovy, Trelegy Ellipta, Xtandi, Pomalyst, Ibrance, Ofev, Linzess, Calquence, Austedo, Breo Ellipta, Tradjenta, Xifaxan, Vraylar, Janumet and Otezla. The negotiated price is what your plan pays. What you pay still depends on your plan's tier, deductible and copay. Here is what the list means for your 2027 drug costs and what to check during Open Enrollment.

Which drugs have Medicare negotiated prices in 2027?

CMS selected 15 drugs covered under Part D for the second round of the Medicare Drug Price Negotiation Program and reached agreements on all of them. The prices take effect January 1, 2027. These are the drugs, with the conditions CMS lists for each, from CMS's selected drugs and negotiated prices page.

These join the first 10 negotiated drugs, such as Eliquis, Jardiance and Januvia, whose prices took effect January 1, 2026.

Will my copay go down on January 1, 2027?

Not necessarily, and this is the most misunderstood part. CMS calls the negotiated amount the maximum fair price. It is the price Medicare drug plans pay for the drug, not a price you are guaranteed at the counter. Your cost is set by your plan: which tier the drug is on, whether you have met the deductible and whether you pay a flat copay or a percentage. If you pay a percentage, called coinsurance, a lower drug price usually lowers what you pay. If you pay a flat copay, it may not change.

The Your Medicare in 2027 fact sheet confirms the timing: prices for the next 15 drugs Medicare negotiated under Part D take effect January 1, 2027. To see your real cost, look up each drug on your plan's 2027 drug list.

How do negotiated prices work with the 2027 Part D cap?

In 2027 the maximum Part D deductible is $700 and the yearly out-of-pocket cap on covered drugs is $2,400. Once your share of covered drug costs reaches the cap, you pay nothing more for covered Part D drugs that year. Lower negotiated prices can slow how quickly you reach the deductible and the cap, which matters most for people on expensive brand-name drugs. Our page on the Part D out-of-pocket maximum for 2027 explains the cap in detail.

Do I need to do anything to get the negotiated price?

No separate sign-up is needed. The price applies through your Medicare drug plan, whether that is a stand-alone Part D plan or a Medicare Advantage plan with drug coverage. What you should do is confirm that your plan covers the drug at all. A plan can still decide which drugs it lists and on which tier. During Open Enrollment, October 15 to December 7, check each drug you take against the plan's 2027 drug list and Annual Notice of Change.

Buying a drug with a discount card or a cash program, such as TrumpRx, is a different path. Those purchases don't count toward your Part D deductible or out-of-pocket cap. Our page on TrumpRx and Part D explains the tradeoff.

What if my plan doesn't cover my drug?

A negotiated price doesn't require a plan to list the drug on its formulary or place it on a low tier. If your current plan drops one of your drugs for 2027 or moves it to a more expensive tier, you have two main options. During Open Enrollment you can switch to a plan that covers it better, with the new plan starting January 1, 2027. You can also ask your plan for an exception, which your doctor supports with a statement about why you need that drug. If you have Extra Help, your copay for brand-name drugs in 2027 is no more than $14.40, and you can change your drug coverage once a month, so the plan choice is less of a one-time bet. Read your Annual Notice of Change as soon as it arrives in the fall so there is time to act.

Will more drugs be added?

Yes. CMS has selected drugs for a third round, including the first drugs covered under Part B, with any new negotiated prices taking effect in 2028. The program is also adding renegotiation of drugs already on the list. Expect the list to grow each year, which is another reason to review your drug coverage every fall rather than letting it renew on autopilot.

What does this mean in North Carolina, South Carolina and Tennessee?

The negotiated prices are national, so they apply to Medicare drug plans in every state. What varies is the plans themselves. The Part D and Medicare Advantage plans sold in Mecklenburg County, in York and Lancaster counties in South Carolina, and in the Nashville area each have their own drug lists, tiers and pharmacy networks. Two neighbors on the same drug can pay very different amounts depending on the plan they picked. If you take one of the 15 drugs, compare 2027 plans by your total yearly drug cost, not by premium alone. Our guide to comparing Part D plans shows how.

How The Jordan Insurance Agency can help

If you take one of these drugs, 2027 is a good year to recheck your coverage. We'll enter your exact prescriptions and pharmacies, compare the plans available in your county and show you the total cost for the year, including how the negotiated prices and the $2,400 cap affect you. If you're managing a parent's medications, bring their list and we'll run it for them too. Schedule Your Consultation to review your options.

Reviewed by Billy Jordan Jr., licensed insurance agent · Licensing & Credentials · Last reviewed November 12, 2026 · Sources are linked in the answer above.

Licensing: Billy Jordan Jr. is licensed in 23 states, including North Carolina, South Carolina and Tennessee. See Licensing & Credentials.

Office: North Carolina and South Carolina clients are served by the Charlotte office, 3540 Toringdon Way, Suite 200, Charlotte, NC 28277, (704) 926-7565. Tennessee clients are served by the Nashville office, 159 4th Ave N, Suite 100, Nashville, TN 37219, (615) 558-6082.

Medicare disclaimer: We do not offer every plan available in your area. Currently we represent 8 organizations which offer 91 products in North Carolina, 7 organizations which offer 70 products in South Carolina, and 7 organizations which offer 65 products in Tennessee. Please contact Medicare.gov or 1-800-MEDICARE to get information on all of your options. Read the full Medicare disclaimer.