The 15 drugs with new Medicare prices in 2027
Under the Medicare Drug Price Negotiation Program, CMS negotiated prices for 15 Part D drugs in its second round. The prices take effect January 1, 2027. CMS lists them below with the conditions each drug commonly treats, the negotiated price for a 30-day supply, and the 2024 list price for comparison.
Medicare-negotiated prices starting January 1, 2027 (30-day supply)
| Drug | Used for | 2027 price (2024 list) |
|---|---|---|
| Ozempic, Rybelsus, Wegovy | Type 2 diabetes; cardiovascular disease; obesity or overweight | $274 ($959) |
| Trelegy Ellipta | Asthma; COPD | $175 ($654) |
| Xtandi | Prostate cancer | $7,004 ($13,480) |
| Pomalyst | Multiple myeloma; Kaposi sarcoma | $8,650 ($21,744) |
| Ofev | Idiopathic pulmonary fibrosis | $6,350 ($12,622) |
| Ibrance | Breast cancer | $7,871 ($15,741) |
| Linzess | Chronic constipation; IBS with constipation | $136 ($539) |
| Calquence | Chronic lymphocytic leukemia; mantle cell lymphoma | $8,600 ($14,228) |
| Austedo, Austedo XR | Huntington's disease chorea; tardive dyskinesia | $4,093 ($6,623) |
| Breo Ellipta | Asthma; COPD | $67 ($397) |
| Xifaxan | Hepatic encephalopathy; IBS with diarrhea | $1,000 ($2,696) |
| Vraylar | Bipolar I disorder; major depressive disorder; schizophrenia | $770 ($1,376) |
| Tradjenta | Type 2 diabetes | $78 ($488) |
| Janumet, Janumet XR | Type 2 diabetes | $80 ($526) |
| Otezla, Otezla XR | Plaque psoriasis; psoriatic arthritis; Behçet's disease oral ulcers | $1,650 ($4,722) |
CMS says about 5.3 million people with Part D were dispensed at least one of these drugs in 2024.
Ozempic, Wegovy and Rybelsus
The semaglutide drugs had the highest total Part D spending of the 15. Their negotiated price is $274 for a 30-day supply, compared with a 2024 list price of $959.
See the numbers
| Item | List price | Negotiated price | Status |
|---|---|---|---|
| Semaglutide (Ozempic, Wegovy, Rybelsus) | $959 | $274 | final |
The Medicare-negotiated price for Ozempic, Wegovy and Rybelsus is $274 for a 30-day supply starting in 2027, compared with a 2024 list price of $959.
Source: CMS — Negotiated prices for initial price applicability year 2027 (fact sheet)
Medicare drug plans cover these drugs for diabetes and certain heart conditions. Coverage for weight loss alone works differently. See the GLP-1 section below.
Will you pay the negotiated price?
Not directly. The negotiated price is what Medicare drug plans pay for the drug. What you pay at the pharmacy is still set by your plan: its deductible, its copay or coinsurance for that drug's tier, and whether the drug stays on its formulary.
If your plan charges coinsurance, a percentage of the price, a lower drug price can lower what you pay. If it charges a flat copay, your cost may not change much. Either way, everything you pay for covered drugs counts toward the $2,400 yearly cap. See the 2027 Part D out-of-pocket max.
What to check during Open Enrollment
- Is your drug on each plan's 2027 formulary? Plans can add or drop drugs each year.
- What tier is it on? The tier sets your copay or coinsurance.
- Does the plan need prior authorization or step therapy? Those rules can change for 2027.
- What is your total cost for the year? Add the premium, the deductible and your drug costs, not just the price of one drug.
Open Enrollment runs October 15, 2026 through December 7, 2026, and changes take effect January 1, 2027.
GLP-1 drugs for weight loss are a separate program
Part D plans generally don't cover drugs used only for weight loss. The Medicare GLP-1 Bridge, which runs July 1, 2026 through December 31, 2027, lets eligible people with Part D get certain GLP-1 drugs for weight loss for a $50 copay with prior authorization. That copay does not count toward the Part D cap.
For who qualifies and which drugs are included, see does Medicare cover Zepbound and Wegovy for weight loss in 2027 and does Medicare cover Ozempic and Wegovy.
Quick questions
Is Ozempic cheaper with Medicare in 2027?
The price Medicare plans pay drops to $274 for a 30-day supply. What you pay depends on your plan's deductible and cost sharing for that drug.
Do I need to switch plans to get the negotiated prices?
No. The prices apply in every Medicare drug plan that covers these drugs. Comparing plans still matters because each plan sets its own copays, tiers and formulary.
Do the negotiated prices apply to Medicare Advantage drug plans?
Yes. They apply to Part D coverage, including Medicare Advantage plans that include drug coverage.
How The Jordan Insurance Agency helps
The Jordan Insurance Agency is an independent agency based in Charlotte, North Carolina. If you take one of these drugs, we check how each 2027 plan in your county covers it, its tier and any prior authorization rules, and what you would pay over the year.
There is no fee for our help. Carriers pay the agent, so your premium is the same whether you enroll with us or on your own.
Next steps: read the 2027 Part D out-of-pocket max and what's changing in Medicare for 2027.
2027 negotiated drug prices checked October 16, 2026. Sources: CMS — Negotiated prices for initial price applicability year 2027 (fact sheet), CMS — Medicare GLP-1 Bridge, Medicare.gov — How much does Medicare drug coverage cost?.
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